INFLUENCE OF VITAMIN-B12 STATUS ON THE INACTIVATION OF METHIONINE SYNTHASE BY NITROUS-OXIDE

被引:17
作者
LANDON, MJ [1 ]
CREAGHBARRY, P [1 ]
MCARTHUR, S [1 ]
CHARLETT, A [1 ]
机构
[1] CLIN RES CTR,MED STAT SECT,HARROW HA1 3UJ,MIDDX,ENGLAND
关键词
ANESTHETICS; GASES; NITROUS OXIDE; ENZYMES; METHIONINE SYNTHASE;
D O I
10.1093/bja/69.1.81
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We have studied the influence of maternal serum B12 concentration on the inactivation of placental methionine synthase activity by nitrous oxide in an obstetric population. This group was known to include patients with a wide range of B12 values. Over 70% of patients were given nitrous oxide either for analgesia during labour or for delivery by Caesarean section, for periods ranging from a few minutes to 11 h. Patients undergoing normal delivery and Caesarean section under extradural anaesthesia served as controls. There was a highly significant relation between placental methionine synthase activity and duration of exposure to nitrous oxide. Inactivation was slower than that described for the liver, which may reflect the intermittent use. There was also a significant relation between maternal B12 and placental methionine synthase activity, but there was a wide scatter of results and the data were not thought to be predictive. There was evidence that inactivation by nitrous oxide was more rapid in patients with small concentrations of B12. We conclude that some patients with reduced serum concentrations of B12 may be at a disadvantage with nitrous oxide anaesthesia.
引用
收藏
页码:81 / 86
页数:6
相关论文
共 25 条
[1]  
[Anonymous], APPL STATIST
[2]   NITROUS-OXIDE AND FORMIMINOGLUTAMIC ACID - EXCRETION IN SURGICAL PATIENTS AND ANESTHETISTS [J].
ARMSTRONG, P ;
RAE, PWH ;
GRAY, WM ;
SPENCE, AA .
BRITISH JOURNAL OF ANAESTHESIA, 1991, 66 (02) :163-169
[3]   SELF-ADMINISTERED INTERMITTENT NITROUS-OXIDE ANALGESIA FOR LABOR - ENHANCEMENT OF EFFECT WITH CONTINUOUS NASAL INHALATION OF 50 PER CENT NITROUS-OXIDE (ENTONOX) [J].
ARTHURS, GJ ;
ROSEN, M .
ANAESTHESIA, 1979, 34 (04) :301-309
[4]  
ATKINSON AC, 1985, PLOTS TRANSFORMATION, P24
[5]  
BERGER JJ, 1988, ANESTH ANALG, V67, P197
[6]  
CHANARIN I, 1985, LANCET, V2, P1168
[7]  
EGER EI, 1990, ANESTH ANALG, V71, P575
[8]   MONITORING COBALAMIN INACTIVATION DURING NITROUS-OXIDE ANESTHESIA BY DETERMINATION OF HOMOCYSTEINE AND FOLATE IN PLASMA AND URINE [J].
ERMENS, AAM ;
REFSUM, H ;
RUPREHT, J ;
SPIJKERS, LJM ;
GUTTORMSEN, AB ;
LINDEMANS, J ;
UELAND, PM ;
ABELS, J .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (04) :385-393
[9]  
KOBLIN DD, 1990, BRIT J ANAESTH, V64, P214
[10]   RECOGNITION OF 2 INTRACELLULAR COBALAMIN BINDING-PROTEINS AND THEIR IDENTIFICATION AS METHYLMALONYL-COA MUTASE AND METHIONINE SYNTHETASE [J].
KOLHOUSE, JF ;
ALLEN, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (03) :921-925