PLATELET IMIPRAMINE BINDING AND SEROTONIN UPTAKE IN OBSESSIVE-COMPULSIVE PATIENTS

被引：26

作者：

VITIELLO, B ^{[1
]}

SHIMON, H ^{[1
]}

BEHAR, D ^{[1
]}

STOFF, D ^{[1
]}

BRIDGER, WH ^{[1
]}

FRIEDMAN, E ^{[1
]}

机构：

[1] EASTERN PENN PSYCHIAT INST,COLL MED,PHILADELPHIA,PA 19129

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1991年 / 84卷 / 01期

关键词：

OBSESSIVE-COMPULSIVE DISORDER; PLATELET; SEROTONIN; UPTAKE;

D O I：

10.1111/j.1600-0447.1991.tb01417.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Platelet imipramine binding was measured in 16 drug-free nondepressed patients (aged 20-61 years, mean +/- SD 35 +/- 8) suffering from obsessive-compulsive disorder (OCD) and in 16 sex-, race- and age-matched healthy controls. Imipramine binding capacity and affinity were not different in the 2 groups. Platelet serotonin (5-HT) uptake capacity, V(max), was also measured in 15 of these patients and their matched controls. V(max) was significantly higher in the patients (309 +/- 149 pmol/ 10(9) cells/min) than in the controls (181 +/- 110). An increase in platelet 5-HT uptake supports the involvement of 5-HT in OCD and may suggest that a hyperactive serotonergic system is present in this disorder.

引用

页码：29 / 32

页数：4

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