CLONING OF THE YAP19 GENE ENCODING A PUTATIVE YEAST HOMOLOG OF AP19, THE MAMMALIAN SMALL CHAIN OF THE CLATHRIN-ASSEMBLY PROTEINS

被引：22

作者：

NAKAI, M ^{[1
]}

TAKADA, T ^{[1
]}

ENDO, T ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,CHIKUSA KU,NAGOYA 46401,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1174卷 / 03期

关键词：

CLATHRIN; COATED VESICLE; ASSEMBLY POLYPEPTIDE; GENE SEQUENCE; (YEAST); (SACCHAROMYCES-CEREVISIAE);

D O I：

10.1016/0167-4781(93)90198-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse brain AP19 is the smallest polypeptide chain component of AP-1, the clathrin-assembly protein complex located at the Golgi complex. We isolated a gene, termed YAP19, potentially encoding a homolog of AP19 from the genomic DNA of the yeast Saccharomyces cerevisiae. The deduced amino acid sequence, 156 amino acids long, shows 53% identity with the mouse brain AP19 protein, but 37% with Yap17p, a yeast homolog of the mammalian AP17 in AP-2, another clathrin-assembly protein complex located at the plasma membrane. The identification of YAP19 supports the proposal that yeast cells also contain the Golgi-associated clathrin-assembly protein complex.

引用

页码：282 / 284

页数：3

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