HYPOTHESIS - SPERMINE MAY BE AN IMPORTANT EPIDERMAL ANTIOXIDANT

被引：34

作者：

LOVAAS, E

机构：

[1] Institute of Biology and Geology, University of Tromsø

来源：

MEDICAL HYPOTHESES | 1995年 / 45卷 / 01期

关键词：

D O I：

10.1016/0306-9877(95)90204-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Spermine has been identified as a potent antioxidant and an anti-inflammatory agent. The compound is present in all organisms and all organs. The concentration is exceptionally high in skin, and I propose that spermine constitutes a prime defence against radiation damage. This hypothesis is substantiated by the fact that ornithine decarboxylase (ODC), the rate-controlling enzyme of spermine biosynthesis, is induced by UVB-irradiation and oxidative stress. On the contrary, inhibition of ODC makes cells more sensitive to radiation damage. The antioxidative effect of spermine may be due to metal chelation and/or to prevention of superoxide generation from stimulated neutrophils. This paper reviews the antioxidative and anti-inflammatory effects of spermine, and suggests that spermine is an important antioxidant of epidermis.

引用

页码：59 / 67

页数：9

共 125 条

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