A SINGLE CHORIONIC-GONADOTROPIN ASSAY FOR MATERNAL SERUM SCREENING FOR DOWNS-SYNDROME

被引：37

作者：

MULLER, F ^{[1
]}

BOUE, A ^{[1
]}

机构：

[1] HOP AMBROISE PARE,F-92104 BOULOGNE,FRANCE

来源：

PRENATAL DIAGNOSIS | 1990年 / 10卷 / 06期

关键词：

Down' s syndrome; Human chorionic gonadotropin assay; Maternal serum screening;

D O I：

10.1002/pd.1970100606

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A simple enzyme immunoassay measuring human chorionic gonadotropin in undiluted maternal serum has been developed in order to be used as a prenatal screening test for Down' s syndrome. A retrospective study of maternal serum sampled during pregnancies associated with trisomy 21 shows that with a 5% amniocentesis rate determined on a single test, the detection rate of trisomy 21 would be around two‐thirds of the affected pregnancies. A prospective study of 9040 pregnant women under 38 years has confirmed the usefulness of the assay. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：389 / 398

页数：10

共 35 条

[1]

ARAB H, 1988, American Journal of Human Genetics, V43, pA225

[2]

BARTELS I, 1988, HUM GENET, V80, P465

[3]

BAUMGARTEN A, 1986, LANCET, V2, P345

[4] SONOGRAPHIC IDENTIFICATION OF 2ND-TRIMESTER FETUSES WITH DOWNS-SYNDROME [J].