INOSITOL DEPENDENT PHOSPHATE-OXYGEN LIGAND-EXCHANGE CATALYZED BY INOSITOL MONOPHOSPHATASE

被引：33

作者：

BAKER, GR

GANI, D

机构：

[1] Chemistry Department, The University, St. Andrews, Fife KY16 9ST, The Purdie Building

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)80250-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inositol monophosphatase is unable to catalyse the exchange of O-18-label from O-18-water into inorganic phosphate in the absence of inositol. The inositol mediated exchange reaction is Mg2+ dependent, shows a similar pH dependence to that for the hydrolysis of myo-inositol 1-phosphate and is inhibited by lithium cation. These results suggest that the enzyme operates via a ternary complex mechanism unlike alkaline and acid phosphatase.

引用

页码：193 / 196

页数：4

共 11 条

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