LABORATORY PREDICTION OF CLINICAL CHEMOTHERAPEUTIC DRUG-RESISTANCE - A WORKING MODEL EXEMPLIFIED BY ACUTE-LEUKEMIA

被引：19

作者：

LARSSON, R ^{[1
]}

NYGREN, P ^{[1
]}

机构：

[1] UNIV HOSP UPPSALA,DIV ONCOL,S-75185 UPPSALA,SWEDEN

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 08期

关键词：

D O I：

10.1016/S0959-8049(05)80316-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent research into mechanisms of resistance to chemotherapy in acute leukaemia has been focused on various protective mechanisms at the cellular level, such as drug uptake, efflux, metabolism and DNA repair mechanisms, while therapeutic failures due to other potentially important causes have received relatively little attention. Here we describe a simple model to account for three major determinants of tumour response in acute leukaemia: cellular drug sensitivity, leukaemic cell regrowth potential and systemic drug exposure. Possible ways of measuring these parameters are discussed. It is suggested that laboratory estimation of these parameters may provide valuable information on clinical drug resistance and may help to design more adequate treatment strategies for the individual patient.

引用

页码：1208 / 1212

页数：5

共 29 条

[1]

BECK WT, 1987, CANCER RES, V47, P5455

[2]

BORSI J, 1987, CANCER TREAT REP, V20, P3020

[3] CORRELATIONS BETWEEN THERAPEUTIC RESPONSE OF LEUKEMIAS AND INVITRO DRUG-SENSITIVITY ASSAY [J].