24-HOUR HOMEODYNAMIC STATES OF ARTERIAL BLOOD-PRESSURE AND PULSE INTERVAL IN CONSCIOUS RATS

In models that describe the homeostasis of the circulation, arterial blood pressure is usually expressed as a single value, which is regarded as the set point in such systems. The aim of the study was to identify in rats from 24-h beat-to-beat recordings the value of blood pressure that describes best such a set point of the cardiovascular system. Normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), kept on a 12:12-h lights on-off cycle, were instrumented for computerized 24-h beat-to-beat recording of mean arterial pressure (MAP) and pulse interval (PI). Three-dimensional frequency distributions were constructed by plotting for each beat its MAP vs. its PI. During the dark period, the concurrent distribution of MAP and PI showed two distinct modes while during the light period a single mode was found. Comparable patterns were found in SHRs and WKYs. These three different modes were significantly different from the mathematically calculated mean values of MAP and PI over these periods. Thus in rats the 24-h behavior of the cardiovascular system is better described by dynamic shifts between different modes (homeodynamic states) than by a single set point.