NUMERICAL-MODEL FOR RADIOFREQUENCY ABLATION OF THE ENDOCARDIUM AND ITS EXPERIMENTAL VALIDATION

被引:98
作者
LABONTE, S
机构
[1] Department of Electrical Engineering, University of Ottawa, Ottawa, Ont.
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1109/10.284921
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A theoretical model for the study of the radio-frequency (RF) ablation technique is presented. The model relies on a finite-element time-domain calculation of the temperature distribution in a block of tissue, resulting from the flow of RF (< 1MHz) electrical current. A thermal damage function is used to calculate the extent of the lesion on the basis of the temperature elevation and the duration of exposure. This work extends the model proposed by Haines [1] by including a more realistic and variable geometry, the cooling effect of the blook flow and a transient analysis. Furthermore, the nonlinearity caused by the temperature dependence of the tissue properties is also considered. The complexity of the model being appreciable, an experiment demonstrating its validity is also described. While remaining workable, the experiment is sophisticated enough to lead to convincing conclusions. It consists in measuring the temperature distribution and the time-dependent electrode resistance during ''ablation'' of a tissue-equivalent material. Various electrode configurations and electrical excitations are investigated. In all cases, the experimental results agree reasonably well with the numerical calculations. This confirms that the model is accurate for the investigation of RF ablation.
引用
收藏
页码:108 / 115
页数:8
相关论文
共 29 条
[1]  
Bennett CO., 1962, MOMENTUM HEAT MASS T
[2]  
BOWMAN HF, 1981, J MICROWAVE POWER EE, V16, P121
[3]  
CARTENSEN EL, 1974, J BIOL PHYS, V2, P173
[5]  
CHATO JC, 1987, HDB BIOENGINEERING
[6]  
EVANS GT, 1990, CIRCULATION S3, V82
[7]  
FOSTER KR, 1989, CRIT REV BIOMED ENG, V17, P25
[8]   ELECTRODE RADIUS PREDICTS LESION RADIUS DURING RADIOFREQUENCY ENERGY HEATING - VALIDATION OF A PROPOSED THERMODYNAMIC MODEL [J].
HAINES, DE ;
WATSON, DD ;
VEROW, AF .
CIRCULATION RESEARCH, 1990, 67 (01) :124-129
[9]   OBSERVATIONS ON ELECTRODE-TISSUE INTERFACE TEMPERATURE AND EFFECT ON ELECTRICAL-IMPEDANCE DURING RADIOFREQUENCY ABLATION OF VENTRICULAR MYOCARDIUM [J].
HAINES, DE ;
VEROW, AF .
CIRCULATION, 1990, 82 (03) :1034-1038
[10]   TISSUE HEATING DURING RADIOFREQUENCY CATHETER ABLATION - A THERMODYNAMIC MODEL AND OBSERVATIONS IN ISOLATED PERFUSED AND SUPERFUSED CANINE RIGHT VENTRICULAR FREE WALL [J].
HAINES, DE ;
WATSON, DD .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1989, 12 (06) :962-976