ORALLY-ADMINISTERED PHOSPHOLIPIDS INHIBIT ABDOMINAL RUBBER-DRAIN-INDUCED BACTERIAL TRANSLOCATION IN THE RAT

In order to determine the influence of phospholipid on abdominal biomaterial-induced bacterial translocation (BT), phsophatidylcholine (PC) or phosphatidylinositol (PI) was administered orally or intraperitoneally in rats with intraperitoneal implantation of 7-cm(2) rubber drain pieces. Two days after surgery, the incidence of translocation to mesenteric lymph nodes and liver significantly decreased, the adherence of H-3-Iabeled Escherichia coli to the ileal mucosa was signifciantly inhibited and the phagocytic and bactericidal capacity of peritoneal macrophages increased in animals with PC or PI administered orally, but not intraperitoneally, as compared with rats without phospholipid administration. Scanning electron microscopy revealed a coating layer on the surface of the intestinal mucosa in phospholipid-gavaged rats. Thus, the results in the present study imply that oral, but not intraperitoneal, PC of PI administration reduces enteric BT induced by intraperitoneal drain implantation.