L-ARGININE NITRIC-OXIDE PATHWAY MODULATES GASTRIC-MOTILITY AND GALLBLADDER EMPTYING INDUCED BY ERYTHROMYCIN AND LIQUID MEAL IN HUMANS

被引:29
作者
FIORUCCI, S
DISTRUTTI, E
QUINTIERI, A
SARPI, L
SPIRCHEZ, Z
GULLA, N
MORELLI, A
机构
[1] UNIV PERUGIA,FARMACOL & PATOL CLIN GASTROENTEROL & ENDOSCOPIA,DIPARTIMENTO MED CLIN,I-06100 PERUGIA,ITALY
[2] UNIV PERUGIA,DIPARTIMENTO CHIRURG,PERUGIA,ITALY
关键词
L-ARGININE; NITRIC OXIDE; GASTRIC MOTILITY; GALLBLADDER EMPTYING;
D O I
10.1007/BF02065553
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There is recent evidence that nitric oxide, a soluble gas produced from L-arginine, is released by the smooth muscle cells and neurons of the gastrointestinal tract where it exerts a myorelaxive action. However, little is known about the effects nitric oxide has on gastric and gallbladder motility during the inter- and postprandial phases in man. We therefore investigated the effects 200 mg/kg/hr L-arginine exerts on the gastric and gallbladder motility induced by 2 mg/kg erythromycin or a liquid meal in 21 subjects in a double-blind, placebo-controlled study. Gastric and gallbladder emptying were evaluated by sonography. Fasting antral motility was expressed as antral motility index (MI). In fasting subjects, L-arginine administration determined a threefold increase in plasma nitrite concentrations. Administration of erythromycin caused a significant rise in the antral MI, which was inhibited by L-arginine (P < 0.05). Ingestion of a liquid meal also significantly increased antral MI, but it returned to basal values 90 min after the end of the meal. Although L-arginine administration caused a significant reduction in the antral MI (P < 0.05), it did not inhibit gastric emptying. L-Arginine provoked an approximately 40% increase in basal gallbladder volume, completely blocked erythromycin-induced emptying, and partially, but significantly, prevented the emptying induced by a liquid meal (P < 0.01). Our study suggests that nitric oxide may be implicated in the physiological modulation of gastric and gallbladder motility during the inter- and postprandial phases in man.
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收藏
页码:1365 / 1371
页数:7
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