SEMISYNTHESIS OF A23187 (CALCIMYCIN) ANALOGS .2. INTRODUCTION OF A METHYL-GROUP ON THE BENZOXAZOLE RING

被引：22

作者：

PRUDHOMME, M ^{[1
]}

DAUPHIN, G ^{[1
]}

GUYOT, J ^{[1
]}

JEMINET, G ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND 2, CHIM ORGAN BIOL LAB, CNRS, ERA 392, F-63170 AUBIERE, FRANCE

来源：

JOURNAL OF ANTIBIOTICS | 1984年 / 37卷 / 06期

关键词：

D O I：

10.7164/antibiotics.37.627

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Semisynthesis of 2 demethylamino A23187 with a methyl group in the 4- or 5-position on the benzene ring were carried out via the cleavage of A23187 oxazole ring and rebuilding of modified benzoxazoles. These compounds release Ca2+ and Mg2+ from [rat liver] mitochondria and keep in part the antibacterial activity of the natural metabolite.

引用

页码：627 / 634

页数：8

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