EFFECT OF DIFFERENT LINOLEIC-ACID INTAKES ON PROSTAGLANDIN BIOSYNTHESIS AND KIDNEY-FUNCTION IN MAN

被引:47
作者
ADAM, O
WOLFRAM, G
机构
关键词
RENAL SODIUM; EXCRETION; METABOLISM; INHIBITORS; RENIN;
D O I
10.1093/ajcn/40.4.763
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Prostaglandin (PG) biosynthesis and kidney function was investigated in 24 adults (23 to 32 yr) during isocaloric formula diet periods, for 2 wk each, providing a linoleic acid supply of 0, 3, 3.5, 4, 6, 8, 13, 17, 18, or 20% of total energy intake. Total protein intake (15 energy %) was constant, as well as 5 g NaCl, 3 g KCl, and 0.6 g cholesterol per 2200 kcal formula diet. The amount of PG metabolites, PG-E Na, and creatinine in 24-h urine increased with augmented linoleic acid intake. Comparing a linoleic acid intake of 0 ans 20 energy %, an increase of Na (8%) and creatinine (16%) in 24-h urine was found on the 5th day of high linoleic acid supply. Coincidently a stimulated PG biosynthesis could be measured. K, water, and PG-F excretion showed no relation to linoleic acid intake. It is concluded that linoleic acid in the diet stimulates PG-E biosynthesis in man, leading to effects in systems which control renal function, and may have clinical relevance for the Na and K balance in man.
引用
收藏
页码:763 / 770
页数:8
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