INCREASED URINARY-EXCRETION OF TRANSFERRING IN CHILDREN WITH TYPE-1 DIABETES-MELLITUS

被引：32

作者：

MARTIN, P

WALTON, C

CHAPMAN, C

BODANSKY, HJ

STICKLAND, MH

机构：

[1] University Department of Medicine, General Infirmary, Leeds

[2] Department of Chemical Pathology, General Infirmary, Leeds

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 01期

关键词：

Children; Microalbuminuria; N‐acetyl‐β‐D‐glucosaminidase; Transferrin; Type 1 diabetes mellitus; α‐1‐Microglobulin;

D O I：

10.1111/j.1464-5491.1990.tb01304.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Urinary transferrin excretion was measured by radioimmunoassay in 74 children with Type 1 diabetes mellitus and in 40 normal children, and compared with urinary excretion of albumin, α‐1‐microglobulin, and N‐acetyl‐β‐D‐glucosaminidase. Urinary transferrin excretion was significantly elevated in diabetic (median (range) 186 (18–1671) mg mol‐creatinine−1) compared with normal (85 (27–668) mg mol‐creatinine−1) children (p < 0.001). Seventeen diabetic children had transferrin excretion above the 95th centile for normal children. In contrast there was no significant increase in urinary albumin excretion in the diabetic children although 8 had urinary albumin excretion which exceeded the 95th centile for normal children (6 of these 8 patients having coexistent urinary hyperexcretion of transferrin). Urinary transferrin excretion correlated significantly with urinary albumin excretion in both normal (rs = 0.62, p < 0.001) and diabetic (rs = 0.61, p < 0.001) children. The indices of proximal renal tubular function (urinary excretion of α‐1‐microglobulin and N‐acetyl‐β‐D‐glucosaminidase) correlated significantly with transferrin excretion in both diabetic (rs = 0.43 and rs = 0.41, p < 0.001) and normal (rs = 0.40, p < 0.02 and rs = 0.53, p < 0.001) children, but not with albumin excretion (rs = 0.20, p > 0.05 and rs = 0.22, p > 0.05). In addition urinary transferrin excretion significantly correlated with urinary glucose concentration (rs = 0.34, p < 0.007) in Type 1 diabetic children. The discrepancy in urinary excretion of transferrin and albumin may reflect impaired proximal renal tubular reabsorption of transferrin and/or altered glomerular basement membrane selectivity for the two proteins. 1990 Diabetes UK

引用

页码：35 / 40

页数：6

共 34 条

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