PHARMACOKINETICS AND BETA-BLOCKING EFFECTS OF TIMOLOL IN POOR AND EXTENSIVE METABOLIZERS OF DEBRISOQUIN

被引：41

作者：

MCGOURTY, JC ^{[1
]}

SILAS, JH ^{[1
]}

FLEMING, JJ ^{[1
]}

MCBURNEY, A ^{[1
]}

WARD, JW ^{[1
]}

机构：

[1] GLENFIELD GEN HOSP,DEPT CLIN PHARMACOL,LEICESTER,ENGLAND

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1985年 / 38卷 / 04期

关键词：

D O I：

10.1038/clpt.1985.195

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：409 / 413

页数：5

共 19 条

[1]

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[3]

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[4]

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[5] THE UPJOHN-AWARD-LECTURE 1981 - THE METABOLISM OF XENOBIOTICS IN DIFFERENT POPULATIONS [J].

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[6]

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[7] DETERMINATION OF DEBRISOQUINE AND ITS 4-HYDROXY METABOLITE IN BIOLOGICAL-FLUIDS BY GAS-CHROMATOGRAPHY WITH FLAME-IONIZATION AND NITROGEN-SELECTIVE DETECTION [J].

LENNARD, MS ;

SILAS, JH ;

SMITH, AJ ;

TUCKER, GT .

JOURNAL OF CHROMATOGRAPHY, 1977, 133 (01) :161-166

[8] OXIDATION PHENOTYPE - A MAJOR DETERMINANT OF METOPROLOL METABOLISM AND RESPONSE [J].

LENNARD, MS ;

SILAS, JH ;

FREESTONE, S ;

RAMSAY, LE ;

TUCKER, GT ;

WOODS, HF .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (25) :1558-1560

[9]

LENNARD MS, 1984, BR J CLIN PHARM, V17, P106

[10]

LEWIS RV, 1984, BRIT J CLIN PHARMACO, V18, pP287

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