A 2ND ENVELOPE GLYCOPROTEIN MEDIATES NEUTRALIZATION OF A PESTIVIRUS, HOG-CHOLERA VIRUS

被引：144

作者：

WEILAND, E ^{[1
]}

AHL, R ^{[1
]}

STARK, R ^{[1
]}

WEILAND, F ^{[1
]}

THIEL, HJ ^{[1
]}

机构：

[1] FED RES CTR VIRUS DIS ANIM,POB 1149,W-7400 TUBINGEN,GERMANY

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 06期

关键词：

D O I：

10.1128/JVI.66.6.3677-3682.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.

引用

页码：3677 / 3682

页数：6

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