SYNTHESIS OF THROMBIN INHIBITOR DUP-714

被引:64
作者
WITYAK, J
EARL, RA
ABELMAN, MM
BETHEL, YB
FISHER, BN
KAUFFMAN, GS
KETTNER, CA
MA, P
MCMILLAN, JL
MERSINGER, LJ
PESTI, J
PIERCE, ME
RANKIN, FW
CHORVAT, RJ
CONFALONE, PN
机构
[1] The Du Pont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0402
关键词
D O I
10.1021/jo00117a024
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The asymmetric synthesis of thrombin inhibitor DuP 714 (1) is described. The route uses the Matteson boronic ester homologation to prepare the key intermediate, alpha-aminoboronic acid 4. New methodology was developed for the formamidination of boroornithine peptides and for pinanediol boronate ester cleavage.
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收藏
页码:3717 / 3722
页数:6
相关论文
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