SYNTHESIS OF THROMBIN INHIBITOR DUP-714

被引：63

作者：

WITYAK, J

EARL, RA

ABELMAN, MM

BETHEL, YB

FISHER, BN

KAUFFMAN, GS

KETTNER, CA

MA, P

MCMILLAN, JL

MERSINGER, LJ

PESTI, J

PIERCE, ME

RANKIN, FW

CHORVAT, RJ

CONFALONE, PN

机构：

[1] The Du Pont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0402

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 12期

关键词：

D O I：

10.1021/jo00117a024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of thrombin inhibitor DuP 714 (1) is described. The route uses the Matteson boronic ester homologation to prepare the key intermediate, alpha-aminoboronic acid 4. New methodology was developed for the formamidination of boroornithine peptides and for pinanediol boronate ester cleavage.

引用

页码：3717 / 3722

页数：6

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