NEW INSIGHTS INTO PROTEASOME FUNCTION - FROM ARCHAEBACTERIA TO DRUG DEVELOPMENT

被引：125

作者：

GOLDBERG, AL ^{[1
]}

机构：

[1] MYOGEN INC,CAMBRIDGE,MA 02139

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 08期

关键词：

D O I：

10.1016/1074-5521(95)90182-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteasome is not simply a 'garbage disposal unit' but also has functions in the control of the cell cycle and immune responses. The structure of an archaebacterial proteasome has recently been determined to high resolution, and provides insight into the unusual mechanism of proteolytic cleavage by the proteasome.

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页码：503 / 508

页数：6

相关论文

共 44 条

[1] INTERFERON-GAMMA INDUCES DIFFERENT SUBUNIT ORGANIZATIONS AND FUNCTIONAL DIVERSITY OF PROTEASOMES [J].

AKI, M ;

SHIMBARA, N ;

TAKASHINA, M ;

AKIYAMA, K ;

KAGAWA, S ;

TAMURA, T ;

TANAHASHI, N ;

YOSHIMURA, T ;

TANAKA, K ;

ICHIHARA, A .

JOURNAL OF BIOCHEMISTRY, 1994, 115 (02) :257-269

[2] FUNCTION AMD ACTIVATION OF NF-KAPPA-B IN THE IMMUNE-SYSTEM [J].

BAEUERLE, PA ;

HENKEL, T .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :141-179

[3] ACTIVATION OF THE ATP-UBIQUITIN-PROTEASOME PATHWAY IN SKELETAL-MUSCLE OF CACHECTIC RATS BEARING A HEPATOMA [J].

BARACOS, VE ;

DEVIVO, C ;

HOYLE, DHR ;

GOLDBERG, AL .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1995, 268 (05) :E996-E1006

[4] PROTEASOME COMPONENTS WITH RECIPROCAL EXPRESSION TO THAT OF THE MHC-ENCODED LMP PROTEINS [J].

BELICH, MP ;

GLYNNE, RJ ;

SENGER, G ;

SHEER, D ;

TROWSDALE, J .

CURRENT BIOLOGY, 1994, 4 (09) :769-776

[5]

CHEN J, 1995, IN PRESS GENES DEV

[6] THE UBIQUITIN-PROTEASOME PROTEOLYTIC PATHWAY [J].

CIECHANOVER, A .

CELL, 1994, 79 (01) :13-21

[7]

DEMARTINO GN, 1994, J BIOL CHEM, V269, P20878

[8]

DEVERAUX Q, 1994, J BIOL CHEM, V269, P7059

[9]

DRISCOLL J, 1990, J BIOL CHEM, V265, P4789

[10] MHC-LINKED LMP GENE-PRODUCTS SPECIFICALLY ALTER PEPTIDASE ACTIVITIES OF THE PROTEASOME [J].

DRISCOLL, J ;

BROWN, MG ;

FINLEY, D ;

MONACO, JJ .

NATURE, 1993, 365 (6443) :262-264

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