MALIGNANT ACTIVATION OF A K-RAS ONCOGENE IN LUNG-CARCINOMA BUT NOT IN NORMAL TISSUE OF THE SAME PATIENT

被引：392

作者：

SANTOS, E ^{[1
]}

MARTINZANCA, D ^{[1
]}

REDDY, EP ^{[1
]}

PIEROTTI, MA ^{[1
]}

DELLAPORTA, G ^{[1
]}

BARBACID, M ^{[1
]}

机构：

[1] IST NAZL STUDIO & CURA TUMORI,I-20133 MILAN,ITALY

来源：

SCIENCE | 1984年 / 223卷 / 4637期

关键词：

D O I：

10.1126/science.6695174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：661 / 664

页数：4

共 31 条

[1] GENERATION OF BALB-MUSV AND HA-MUSV BY TYPE-C VIRUS TRANSDUCTION OF HOMOLOGOUS TRANSFORMING GENES FROM DIFFERENT SPECIES
ANDERSEN, PR
DEVARE, SG
TRONICK, SR
ELLIS, RW
AARONSON, SA
SCOLNICK, EM
[J]. CELL, 1981, 26 (01) : 129 - 134
[2] ACTIVATION OF KI-RAS 2 GENE IN HUMAN-COLON AND LUNG CARCINOMAS BY 2 DIFFERENT POINT MUTATIONS
CAPON, DJ
SEEBURG, PH
MCGRATH, JP
HAYFLICK, JS
EDMAN, U
LEVINSON, AD
GOEDDEL, DV
[J]. NATURE, 1983, 304 (5926) : 507 - 513
[3] DETECTION OF SICKLE-CELL BETA-S-GLOBIN ALLELE BY HYBRIDIZATION WITH SYNTHETIC OLIGONUCLEOTIDES
CONNER, BJ
REYES, AA
MORIN, C
ITAKURA, K
TEPLITZ, RL
WALLACE, RB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (01): : 278 - 282
[4] CELLULAR TRANSFORMING GENES
COOPER, GM
[J]. SCIENCE, 1982, 217 (4562) : 801 - 806
[5] TRANSFORMING GENES OF HUMAN BLADDER AND LUNG-CARCINOMA CELL-LINES ARE HOMOLOGOUS TO THE RAS GENES OF HARVEY AND KIRSTEN SARCOMA-VIRUSES
DER, CJ
KRONTIRIS, TG
COOPER, GM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11): : 3637 - 3640
[6] THE P21 SRC GENES OF HARVEY AND KIRSTEN SARCOMA-VIRUSES ORIGINATE FROM DIVERGENT MEMBERS OF A FAMILY OF NORMAL VERTEBRATE GENES
ELLIS, RW
DEFEO, D
SHIH, TY
GONDA, MA
YOUNG, HA
TSUCHIDA, N
LOWY, DR
SCOLNICK, EM
[J]. NATURE, 1981, 292 (5823) : 506 - 511
[7] TRANSFORMING GENES OF HUMAN HEMATOPOIETIC TUMORS - FREQUENT DETECTION OF RAS-RELATED ONCOGENES WHOSE ACTIVATION APPEARS TO BE INDEPENDENT OF TUMOR PHENOTYPE
EVA, A
TRONICK, SR
GOL, RA
PIERCE, JH
AARONSON, SA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16): : 4926 - 4930
[8] MUTATION AFFECTING THE 12TH AMINO-ACID OF THE C-HA-RAS ONCOGENE PRODUCT OCCURS INFREQUENTLY IN HUMAN CANCER
FEINBERG, AP
VOGELSTEIN, B
DROLLER, MJ
BAYLIN, SB
NELKIN, BD
[J]. SCIENCE, 1983, 220 (4602) : 1175 - 1177
[9] ISOLATION AND PRELIMINARY CHARACTERIZATION OF A HUMAN TRANSFORMING GENE FROM T24 BLADDER-CARCINOMA CELLS
GOLDFARB, M
SHIMIZU, K
PERUCHO, M
WIGLER, M
[J]. NATURE, 1982, 296 (5856) : 404 - 409
[10] IDENTIFICATION OF TRANSFORMING GENE IN 2 HUMAN SARCOMA CELL-LINES AS A NEW MEMBER OF THE RAS GENE FAMILY LOCATED ON CHROMOSOME-1
HALL, A
MARSHALL, CJ
SPURR, NK
WEISS, RA
[J]. NATURE, 1983, 303 (5916) : 396 - 400

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