A VIRION-SPECIFIC INHIBITORY MOLECULE WITH THERAPEUTIC POTENTIAL FOR HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：36

作者：

MATSUDA, Z ^{[1
]}

YU, XF ^{[1
]}

YU, QC ^{[1
]}

LEE, TH ^{[1
]}

ESSEX, M ^{[1
]}

机构：

[1] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 08期

关键词：

AIDS; ANTIRETROVIRAL THERAPY; VPX PROTEIN;

D O I：

10.1073/pnas.90.8.3544

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A potential new approach for gene therapy against human immunodeficiency virus type 1 (HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+ human T cells. This demonstrates the therapeutic potential of an accessory gene-based virion-specific inhibitory molecule. Vpx and its derivatives can be regarded as a new class of anti-HIV-1 molecule.

引用

页码：3544 / 3548

页数：5

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