RECOMBINANT SECRETED HEMAGGLUTININ PROTECTS MICE AGAINST A LETHAL CHALLENGE OF INFLUENZA-VIRUS

被引：20

作者：

VANLANDSCHOOT, P ^{[1
]}

MAERTENS, G ^{[1
]}

JOU, WM ^{[1
]}

FIERS, W ^{[1
]}

机构：

[1] STATE UNIV GHENT,MOLEC BIOL LAB,KL LEDEGANCKSTR 35,B-9000 GHENT,BELGIUM

来源：

VACCINE | 1993年 / 11卷 / 12期

关键词：

INFLUENZA VIRUS; HEMAGGLUTININ; RECOMBINANT; PROTECTION; RIBI ADJUVANT; VACCINE;

D O I：

10.1016/0264-410X(93)90040-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Balb/c mice were immunized with 2 x 2 mug of purified recombinant secreted haemagglutinin, derived from the A/Victoria/3/75 (H3N2) virus. In the first immunization, Ribi adjuvant was used, while for the booster injection a monophosphoryl lipid A/muramyl dipeptide combination was chosen. Mice immunized in this way were 90-100% protected against a challenge with 20 LD50 of mouse-adapted, homologous virus (strain X47). Bromelain-solubilized haemagglutinin gave only 70% protection under comparable conditions.

引用

页码：1185 / 1187

页数：3

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