EFFECT OF SODIUM POLYSTYRENE SULFONATE ON LITHIUM BIOAVAILABILITY

被引：34

作者：

BELANGER, DR ^{[1
]}

TIERNEY, MG ^{[1
]}

DICKINSON, G ^{[1
]}

机构：

[1] OTTAWA GEN HOSP,DEPT PHARM SERV,501 SMYTH RD,OTTAWA K1H 8L6,ONTARIO,CANADA

来源：

ANNALS OF EMERGENCY MEDICINE | 1992年 / 21卷 / 11期

关键词：

LITHIUM; SODIUM POLYSTYRENE SULFONATE;

D O I：

10.1016/S0196-0644(05)81893-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To examine the effect of a single dose of sodium polystyrene sulfonate and sorbitol on lithium absorption. Design: Prospective, randomized, crossover. Setting: University teaching hospital. Type of participants: Healthy volunteers. Interventions: Subjects ingested 600 mg lithium carbonate on two occasions, with and without 30 g concomitant sodium polystyrene sulfonate. Blood samples were drawn up to 24 hours after ingestion and assayed for serum lithium concentration. Measurements and main results: Compared with control, sodium polystyrene sulfonate and sorbitol reduced the area under the lithium serum concentration-time curve by 11.33%, reduced the mean observed peak serum lithium concentration 0.07 +/- 0.08 mmol/L, and delayed the time to the mean observed peak serum lithium concentration by 2.04 +/- 2.40 hours. Conclusion: Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be instituted promptly.

引用

页码：1312 / 1315

页数：4

共 9 条

[1]

Ellenhorn, Barceloux, Medical Toxicology: Diagnosis and Treatment of Human Poisoning, pp. 1042-1046, (1988)

[2]

Favin, Klein-Schwartz, Oderda, Et al., In vitro study of lithium carbonate absorption by activated charcoal, Clin Toxicol, 26, pp. 443-450, (1988)

[3]

Smith, Ling, Haistenson, Whole-bowel irrigation as a treatment for acute lithium overdose, Ann Emerg Med, 20, pp. 536-539, (1991)

[4]

Linakis, Lacouture, Eisenberg, Et al., Multiple-dose sodium polystyrene sulfonate in lithium intoxication: An animal model, Vet Hum Toxicol, 31, (1989)

[5]

Welch, Driscoll, Lewander, Et al., In vitro lithium binding with sodium polystyrene sulfonate, Vet Hum Toxicol, 29, (1987)

[6]

AVL 985-S Owner's Manual, (1988)

[7]

Colton, Statistics in Medicine, pp. 142-144, (1974)

[8]

Filippone, Fish, Lacouture, Et al., Reversible absorption (desorption) or aspirin from activated charcoal, Arch Intern Med, 147, pp. 1390-1392, (1987)

[9]

Keller, Schwab, Krenzelok, Contribution of sorbitol combined with activated charcoal in prevention of salicylate absorption, Ann Emerg Med, 19, pp. 654-656, (1990)

← 1 →