EFFECTS OF SYSTEMIC L-TYROSINE ON DOPAMINE RELEASE FROM RAT CORPUS STRIATUM AND NUCLEUS ACCUMBENS

被引：41

作者：

DURING, MJ ^{[1
]}

ACWORTH, IN ^{[1
]}

WURTMAN, RJ ^{[1
]}

机构：

[1] MIT, DEPT BRAIN & COGNIT SCI, NEUROENDOCRINE REGULAT LAB, E25-604, CAMBRIDGE, MA 02139 USA

来源：

BRAIN RESEARCH | 1988年 / 452卷 / 1-2期

关键词：

D O I：

10.1016/0006-8993(88)90043-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral dialysis was used to monitor extracellular fluid from rat striatum and nucleus accumbens following the intraperitoneal administration of tyrosine. Dopamine concentrations in dialysates from both the striatum and the nucleus accumbens increased significantly in response to the tyrosine. The magnitude of the tyrosine effect was greater in the nucleus accumbens than in the striatum. Hence, mesolimbic dopaminergic neurons may be especially responsive to precursor availability.

引用

页码：378 / 380

页数：3

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