TARGET DEPENDENCE OF MOTONEURONAL SURVIVAL - THE CURRENT STATUS

The concept that target-derived molecules are essential for the maintenance of motoneuronal survival has now received considerable support from different sources. One source of information arises from the target-related motoneuron death that occurs naturally at early developmental stages. Another source of information arises from axotomy-induced motoneuron death in adulthood. During development, the survival of motoneurons is initially target-independent. Its target dependence is expressed at a certain embryonic stage and, subsequently, motoneuronal survival becomes less dependent upon the target. It is not known how the state-switch of motoneurons is induced during development. Also, it is not certain whether naturally occurring motoneuron death during development and axotomy-induced motoneuron death in adulthood are based on the same mechanisms. Axotomy induces injury-associated disturbance in the motoneurons, in addition to elimination of the target-derived trophic supply. At present, there is no direct evidence that axotomy-induced motoneuron death in adulthood results solely from the deprivation of trophic factors from the target. The survival of motoneuron in adulthood appears to be maintained by multiple mechanisms. Some of the trophic factors that are involved in the maintenance of neuronal phenotypic expression are distinct from those involved in the maintenance of neuronal survival. There are multiple target-derived trophic factors for a given neuron.