STEREOSELECTIVE SYNTHESIS OF HR 780 A NEW HIGHLY POTENT HMG-COA REDUCTASE INHIBITOR

被引：75

作者：

WESS, G

KESSELER, K

BAADER, E

BARTMANN, W

BECK, G

BERGMANN, A

JENDRALLA, H

BOCK, K

HOLZSTEIN, G

KLEINE, H

SCHNIERER, M

机构：

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 18期

关键词：

D O I：

10.1016/0040-4039(90)80121-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated. © 1990.

引用

页码：2545 / 2548

页数：4

共 18 条

[1] ARAI M, 1987, DRUGS FUTURE, V12, P437
[2] ARAI M, 1989, DRUGS FUTURE, V14, P481
[3] Arai M, 1988, SANKYO KENKYUSHO NEM, V40, P1
[4] BAADER E, 1989, 7TH P NOORDW CAM S T
[5] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW HMG-COA REDUCTASE INHIBITORS .1. LACTONES OF PYRIDINE-SUBSTITUTED AND PYRIMIDINE-SUBSTITUTED 3,5-DIHYDROXY-6-HEPTENOIC (-HEPTANOIC) ACIDS
BECK, G
KESSELER, K
BAADER, E
BARTMANN, W
BERGMANN, A
GRANZER, E
JENDRALLA, H
VONKEREKJARTO, B
KRAUSE, R
PAULUS, E
SCHUBERT, W
WESS, G
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) : 52 - 60
[6] A NOVEL METHOD FOR THE INSITU GENERATION OF ALKOXYDIALKYLBORANES AND THEIR USE IN THE SELECTIVE PREPARATION OF 1,3-SYN DIOLS
CHEN, KM
GUNDERSON, KG
HARDTMANN, GE
PRASAD, K
REPIC, O
SHAPIRO, MJ
[J]. CHEMISTRY LETTERS, 1987, (10) : 1923 - 1926
[7] 1,3-SYN DIASTEREOSELECTIVE REDUCTION OF BETA-HYDROXYKETONES UTILIZING ALKOXYDIALKYLBORANES
CHEN, KM
HARDTMANN, GE
PRASAD, K
REPIC, O
SHAPIRO, MJ
[J]. TETRAHEDRON LETTERS, 1987, 28 (02) : 155 - 158
[8] GRUNDY SM, 1988, NEW ENGL J MED, V319, P24
[9] LOVASTATIN - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC PROPERTIES AND THERAPEUTIC USE IN HYPERLIPEMIA
HENWOOD, JM
HEEL, RC
[J]. DRUGS, 1988, 36 (04) : 429 - 454
[10] SYNTHESIS OF AN HMG-COA REDUCTASE INHIBITOR - A DIASTEREOSELECTIVE ALDOL APPROACH
LYNCH, JE
VOLANTE, RP
WATTLEY, RV
SHINKAI, I
[J]. TETRAHEDRON LETTERS, 1987, 28 (13) : 1385 - 1388

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