STEREOSELECTIVE SYNTHESIS OF HR 780 A NEW HIGHLY POTENT HMG-COA REDUCTASE INHIBITOR

被引:75
作者
WESS, G
KESSELER, K
BAADER, E
BARTMANN, W
BECK, G
BERGMANN, A
JENDRALLA, H
BOCK, K
HOLZSTEIN, G
KLEINE, H
SCHNIERER, M
机构
关键词
D O I
10.1016/0040-4039(90)80121-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated. © 1990.
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页码:2545 / 2548
页数:4
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