PHARMACOLOGICAL AND BIOCHEMICAL-PROPERTIES OF INSECT GABA RECEPTORS

被引：71

作者：

RAUH, JJ ^{[1
]}

LUMMIS, SCR ^{[1
]}

SATTELLE, DB ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,AFRC,MOLEC SIGNALLING LAB,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 08期

关键词：

1,2,3,4-tetrahydro-1-methyl-3-puridinecarboxylic acid; 3-(piperazinyl-1)-9H-dibenz[c.f]triazolo[4,5-α]azepin; 3-aminopropane sulphonic acid; 3-APS; 3α-hydroxy-16-imino-5β; 17-azaandrostane-11-one; 4-purodiazepine; isoguvacine; P4S; piperidine-4-sulphonic acid; pitrazepin; Ro54864; RU5135; t-bulylbicyclophosphorothionate; t-butylbicycloorthobenzoate; TBOB; TBPS;

D O I：

10.1016/0165-6147(90)90236-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The first evidence for the existence of GABA receptors in any tissue was provided by studies on an invertebrate preparation but, until recently, characterization of GABA receptors from such lower organisms has advanced slowly. The identification of GABA receptors as putative target sites for a variety of insecticidal agents has contributed to the resurgence of interest in amino acid receptors of insects and other invertebrates. In this review, James Rauh and colleagues describe the properties of GABA receptors of insects and detail some striking pharmacological differences between the well-characterized GABA receptors of vertebrates and those of insects and other invertebrate organisms. A detailed understanding of invertebrate receptor pharmacology will be increasingly important for defining the mode of action of numerous modern pesticides. © 1990.

引用

页码：325 / 329

页数：5

共 39 条

[1] BIOCHEMICAL-IDENTIFICATION OF PUTATIVE GABA BENZODIAZEPINE RECEPTORS IN HOUSEFLY THORAX MUSCLES [J].

ABALIS, IM ;

ELDEFRAWI, ME ;

ELDEFRAWI, AT .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1983, 20 (01) :39-48

[2] HIGH-AFFINITY STEREOSPECIFIC BINDING OF CYCLODIENE INSECTICIDES AND GAMMA-HEXACHLOROCYCLOHEXANE TO GAMMA-AMINOBUTYRIC ACID RECEPTORS OF RAT-BRAIN [J].

ABALIS, IM ;

ELDEFRAWI, ME ;

ELDEFRAWI, AT .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1985, 24 (01) :95-102

[3] EFFECTS OF INSECTICIDES ON GABA-INDUCED CHLORIDE INFLUX INTO RAT-BRAIN MICROSACS [J].

ABALIS, IM ;

ELDEFRAWI, ME ;

ELDEFRAWI, AT .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1986, 18 (01) :13-23

[4] MOLECULAR-BIOLOGY OF THE GABA-A RECEPTOR - THE RECEPTOR CHANNEL SUPERFAMILY [J].

BARNARD, EA ;

DARLISON, MG ;

SEEBURG, P .

TRENDS IN NEUROSCIENCES, 1987, 10 (12) :502-509

[5]

BROOKES N, 1973, MOL PHARMACOL, V9, P571

[6] FURTHER CHARACTERIZATION OF THE [S-35]-TBPS BINDING-SITE OF THE GABA RECEPTOR COMPLEX IN LOCUST (SCHISTOCERCA-GREGARIA) GANGLIA MEMBRANES [J].

BROWN, MCS ;

LUNT, GC ;

STAPLETON, A .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1989, 92 (01) :9-13

[7]

COHEN E, 1986, LIFE SCI, V36, P1837

[8] QUALITATIVE VARIATION OF PHOTOLABELED BENZODIAZEPINE RECEPTORS IN DIFFERENT SPECIES [J].

HEBEBRAND, J ;

FRIEDL, W ;

LENTES, KU ;

PROPPING, P .

NEUROCHEMISTRY INTERNATIONAL, 1986, 8 (02) :267-271

[9] STUDIES INVOLVING AVERMECTIN AND THE 4-AMINOBUTYRIC ACID (GABA) RECEPTOR OF ASCARIS-SUUM MUSCLE [J].

HOLDENDYE, L ;

HEWITT, GM ;

WANN, KT ;

KROGSGAARDLARSEN, P ;

WALKER, RJ .

PESTICIDE SCIENCE, 1988, 24 (03) :231-245

[10] RESPONSES TO GABA BY ISOLATED INSECT NEURONAL SOMATA - PHARMACOLOGY AND MODULATION BY A BENZODIAZEPINE AND A BARBITURATE [J].

LEES, G ;

BEADLE, DJ ;

NEUMANN, R ;

BENSON, JA .

BRAIN RESEARCH, 1987, 401 (02) :267-278

← 1 2 3 4 →