1-M-CHLOROPHENYLPIPERAZINE IS AN ACTIVE METABOLITE COMMON TO THE PSYCHOTROPIC-DRUGS TRAZODONE, ETOPERIDONE AND MEPIPRAZOLE

被引:48
作者
FONG, MH [1 ]
GARATTINI, S [1 ]
CACCIA, S [1 ]
机构
[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY
关键词
D O I
10.1111/j.2042-7158.1982.tb04701.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:674 / 675
页数:2
相关论文
共 23 条
[1]   TRAZODONE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN DEPRESSION AND ANXIETY [J].
BROGDEN, RN ;
HEEL, RC ;
SPEIGHT, TM ;
AVERY, GS .
DRUGS, 1981, 21 (06) :401-429
[2]   PLASMA-CONCENTRATIONS OF TRAZODONE AND 1-(3-CHLOROPHENYL) PIPERAZINE IN MAN AFTER A SINGLE ORAL DOSE OF TRAZODONE [J].
CACCIA, S ;
FONG, MH ;
GARATTINI, S ;
ZANINI, MG .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (09) :605-606
[3]   (-)-M-CHLOROPHENYL-PIPERAZINE, A CENTRAL 5-HYDROXYTRYPTAMINE AGONIST, IS A METABOLITE OF TRAZODONE [J].
CACCIA, S ;
BALLABIO, M ;
SAMANIN, R ;
ZANINI, MG ;
GARATTINI, S .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (07) :477-478
[4]   DETERMINATION OF PLASMA AND BRAIN CONCENTRATIONS OF TRAZODONE AND ITS METABOLITE, 1-M-CHLOROPHENYLPIPERAZINE, BY GAS-LIQUID-CHROMATOGRAPHY [J].
CACCIA, S ;
BALLABIO, M ;
FANELLI, R ;
GUISO, G ;
ZANINI, MG .
JOURNAL OF CHROMATOGRAPHY, 1981, 210 (02) :311-318
[5]   BLOCKADE BY TRAZODONE OF NALOXONE-PRECIPITATED JUMPING IN MORPHINE-DEPENDENT RATS - CORRELATION WITH BRAIN LEVELS OF M-CHLOROPHENYLPIPERAZINE [J].
CERVO, L ;
BALLABIO, M ;
CACCIA, S ;
SAMANIN, R .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (12) :813-814
[6]   CONTROLLED CLINICAL TRIAL OF MEPIPRAZOLE IN IRRITABLE BOWEL SYNDROME [J].
DOTEVALL, G ;
GROLL, E .
BRITISH MEDICAL JOURNAL, 1974, 4 (5935) :16-18
[7]   DISPOSITION AND PHARMACOLOGICAL EFFECTS OF M-CHLOROPHENYLPIPERAZINE IN RATS [J].
FULLER, RW ;
SNODDY, HD ;
MASON, NR ;
OWEN, JE .
NEUROPHARMACOLOGY, 1981, 20 (02) :155-162
[8]   EFFECT OF MEPIPRAZOLE ON CENTRAL MONOAMINE NEURONS - EVIDENCE FOR INCREASED 5-HYDROXYTRYPTAMINE AND DOPAMINE RECEPTOR ACTIVITY [J].
FUXE, K ;
AGNATI, LF ;
UNGERSTEDT, U .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 35 (01) :93-107
[9]  
GONCALVES N, 1972, PSYCHOPHARMACOLOGIA, V20, P281
[10]  
INVERNIZZI R, 1981, Neurochemistry International, V3, P239, DOI 10.1016/0197-0186(81)90006-1