EFFECT OF IMMUNOMODULATOR THYMOPENTIN ON IMPAIRED SERORESPONSE TO INFLUENZA VACCINE IN PATIENTS ON HEMODIALYSIS

被引：18

作者：

BEYER, WEP

NOORDZIJ, TC

KRAMER, P

DIDERICH, PPMN

DENHOEK, CTO

JANSSEN, J

MASUREL, N

WEIMAR, W

机构：

[1] UNIV HOSP ROTTERDAM DIJKZIGT,DEPT INTERNAL MED,ROTTERDAM,NETHERLANDS

[2] ST FRANCISCUS GASTHUIS,ROTTERDAM,NETHERLANDS

[3] DIATEL RIJNMOND,IJSSEL,NETHERLANDS

[4] ST CLARA HOSP,ROTTERDAM,NETHERLANDS

来源：

NEPHRON | 1990年 / 54卷 / 04期

关键词：

haemodialysis; humoral response; immunomodulation; influenza vaccination; thymopentin;

D O I：

10.1159/000185883

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In a double-blind placebo-controlled multicentre study, the effect of the immunomodulator thymopentin (TP5) on the antibody production to trivalent influenza vaccine was tested in 108 patients on chronic intermittent haemodialysis (HD). Antibody production was determined in pre- and postvaccination sera. Compared to a group of 35 young healthy adult control subjects, HD patients showed a clearly impaired seroresponsiveness to all three vaccine components, regardless of treatment with TP5 or placebo. We conclude that TP5 administration is not able to enhance humoral immunity in patients on chronic intermittent HD.

引用

页码：296 / 301

页数：6

共 29 条

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