ADMINISTRATION OF CARBACHOL INTO THE LATERAL VENTRICLE AND SUPRACHIASMATIC NUCLEUS (SCN) PRODUCES DOSE-DEPENDENT PHASE-SHIFTS IN THE CIRCADIAN-RHYTHM OF LOCOMOTOR-ACTIVITY

被引：25

作者：

WEE, BEF ^{[1
]}

ANDERSON, KD ^{[1
]}

KOUCHIS, NS ^{[1
]}

TUREK, FW ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,DEPT NEUROBIOL & PHYSIOL,EVANSTON,IL 60208

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 02期

关键词：

CARBACHOL; CIRCADIAN RHYTHM; SUPRACHIASMATIC NUCLEUS; LOCOMOTOR ACTIVITY; PHASE SHIFT; DOSE RESPONSE CURVE; LATERAL VENTRICLE; ACETYLCHOLINE;

D O I：

10.1016/0304-3940(92)90406-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cholinergic agonist, carbachol, induces phase-dependent shifts in the timing of the circadian rhythm of locomotor activity (CRLA). The effects of carbachol injections into the lateral ventricles of hamsters were compared between circadian times that produce phase delays vs. phase advances in the CRLA. The shape of the dose-response curves and the ED50 for carbachol injections were similar for the two injection times. The second experiment demonstrated the dose-dependence of phase advances produced by carbachol injections into the area of the suprachiasmatic nucleus. These results indicate that carbachol exerts similar dose-dependent actions for both phase advances and phase delays.

引用

页码：211 / 215

页数：5

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