DYNAMIN - MOTOR PROTEIN OR REGULATORY GTPASE

Most of the genetic and cytochemical analysis of dynamin supports a role in membrane sorting, with little indication of a role for microtubules. None the less, evidence for such a role persists from in vitro experiments. The most obvious solution to this dilemma seems to be that, despite evidence for specificity of the interaction with microtubules from in vitro work, microtubules mimic a yet-to-be-identified cellular regulator of dynamin function. Alternatively, microtubules may participate in the early stages of endocytosis in a previously unrecognized manner, perhaps even indirectly. Resolving these issues will clearly be of paramount interest in the next phase of experimentation. © 1992 Chapman & Hall.