RADIOTHERAPY ALONE VERSUS COMBINED CHEMOTHERAPY AND RADIOTHERAPY IN UNRESECTABLE NONSMALL CELL LUNG-CARCINOMA

被引：97

作者：

LECHEVALIER, T

ARRIAGADA, R

QUOIX, E

RUFFIE, P

MARTIN, M

DOUILLARD, JY

TARAYRE, M

LACOMBETERRIER, MJ

LAPLANCHE, A

机构：

[1] CHR STRASBOURG, F-67005 STRASBOURG, FRANCE

[2] CTR HOSP INTERCOMMUNAL CRETEIL, F-94010 CRETEIL, FRANCE

[3] CTR RENE GAUDUCHEAU, NANTES, FRANCE

来源：

LUNG CANCER | 1994年 / 10卷

关键词：

RANDOMIZED STUDY; CHEMOTHERAPY; RADIOTHERAPY; LOCALLY ADVANCED NONSMALL CELL LUNG CARCINOMA;

D O I：

10.1016/0169-5002(94)91687-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the results observed in a large randomized study comparing radiotherapy alone to combined radiotherapy and chemotherapy in unresectable squamous cell and large cell lung carcinoma. Radiation dose was 65 Gy in both groups and chemotherapy included vindesine, cyclophosphamide, cisplatin and lomustine. One hundred seventy-seven patients received radiotherapy alone, and 176 received the combined treatment. The 2-year survival rate was 14% for patients receiving radiotherapy vs. 21% for patients receiving the combined treatment (P = 0.02). The distant metastasis rate was significantly lower in the group receiving the combined treatment (P < 0.001). Local control at 1 year was poor in both groups (17% and 15%, respectively) and remains a major problem in locally advanced non-small cell lung cancer.

引用

页码：S239 / S244

页数：6

共 17 条

[1]

COX JD, 1983, CANCER TREAT REP, V67, P327

[2]

GRALLA RJ, 1988, SEMIN ONCOL, V15, P8

[3]

GRECO FA, 1986, SEMIN ONCOL, V13, P92

[4] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

[5]

LECHEVALIER T, 1985, CANCER TREAT REP, V69, P469

[6] EARLY METASTATIC CANCER OF UNKNOWN PRIMARY ORIGIN AT PRESENTATION - A CLINICAL-STUDY OF 302 CONSECUTIVE AUTOPSIED PATIENTS [J].

LECHEVALIER, T ;

CVITKOVIC, E ;

CAILLE, P ;

HARVEY, J ;

CONTESSO, G ;

SPIELMANN, M ;

ROUESSE, J .

ARCHIVES OF INTERNAL MEDICINE, 1988, 148 (09) :2035-2039

[7] RADIOTHERAPY ALONE VERSUS COMBINED CHEMOTHERAPY AND RADIOTHERAPY IN NONRESECTABLE NON-SMALL-CELL LUNG-CANCER - 1ST ANALYSIS OF A RANDOMIZED TRIAL IN 353 PATIENTS [J].

LECHEVALIER, T ;

ARRIAGADA, R ;

QUOIX, E ;

RUFFIE, P ;

MARTIN, M ;

TARAYRE, M ;

LACOMBETERRIER, MJ ;

DOUILLARD, JY ;

LAPLANCHE, A .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (06) :417-423

[8]

LECHEVALIER T, 1992, J NATL CANCER I, V84, P58

[9]

MOUNTAIN CF, 1986, CHEST, V89, pS225, DOI 10.1378/chest.89.4_Supplement.225S

[10]

PEREZ CA, 1982, CANCER-AM CANCER SOC, V50, P1091, DOI 10.1002/1097-0142(19820915)50:6<1091::AID-CNCR2820500612>3.0.CO

← 1 2 →