SYSTEMIC ADMINISTRATION OF GM1 GANGLIOSIDE INCREASES CHOLINE-ACETYLTRANSFERASE ACTIVITY IN THE BRAIN OF AGED RATS

被引：18

作者：

FONG, TG

NEFF, NH

HADJICONSTANTINOU, M

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT PSYCHIAT, COLUMBUS, OH 43210 USA

[2] OHIO STATE UNIV, COLL MED, PROGRAM NEUROSCI, COLUMBUS, OH 43210 USA

来源：

EXPERIMENTAL NEUROLOGY | 1995年 / 132卷 / 02期

关键词：

D O I：

10.1016/0014-4886(95)90020-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the brain of aged rats (22-24 months old) choline acetyltransferase (ChAT) activity in striatum and frontal cortex is lower than in young rats (4-5 months old). In contrast, ChAT activity in the hippocampus is similar in the two groups. Treating old animals with GM1 ganglioside, 30 mg/kg ip, for 30 or 45 days enhances ChAT activity in the striatum and frontal cortex, but has no effect on activity in the hippocampus. ChAT activity remains elevated in the striatum and frontal cortex for 15 days after discontinuing treatment with GM1. (C) 1995 Academic Press, Inc.

引用

页码：157 / 161

页数：5

共 46 条

[1] Alberch, Perez-Navarro, Arenas, Marsal, Involvement of nerve growth factor and its receptor in the regulation of cholinergic function in aged rats, J. Neurochem., 57, pp. 1483-1487, (1991)
[2] Allen, MacGowan, Treanor, Feeney, Wilcock, Dawbarn, Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus, Neurosci. Lett., 131, pp. 135-139, (1991)
[3] Altavista, Bentivoglio, Crociani, Rossi, Albanese, Age-dependent loss of cholinergic neurons in basal ganglia of rats, Brain Res., 455, pp. 177-181, (1988)
[4] Altavista, Rossi, Bentivoglio, Crociani, Albanese, Aging is associated with diffuse loss of forebrain cholinergic neurons, Brain Res., 508, pp. 51-59, (1990)
[5] Appel, A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism and Alzheimer disease, Ann. Neurol., 10, pp. 499-505, (1981)
[6] Bartus, Dean, Beer, Lippa, The cholinergic hypothesis of geriatric memory dysfunction, Science, 217, pp. 408-417, (1982)
[7] Crutcher, Scott, Liang, Everson, Weingartner, Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease, J. Neurosci., 13, pp. 2540-2550, (1993)
[8] Cuello, Glycosphingolipids that can regulate nerve growth and repair, Adv. Pharmacol., 21, pp. 1-50, (1990)
[9] Cuello, Garofalo, Kenigsberg, Maysinger, Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neuron, Proc. Natl. Acad. Sci. USA, 86, pp. 2056-2060, (1989)
[10] Dalia, Neff, Hadjiconstantinou, GM1 ganglioside improves dopaminergic markers of rat mesencephalic cultures treated with MPP<sup>+</sup>, J. Neurosci., 13, pp. 3104-3111, (1993)

← 1 2 3 4 5 →