PROCONFLICT EFFECT OF ACTH1-24 - INTERACTION WITH BENZODIAZEPINES

被引：19

作者：

CORDA, MG ^{[1
]}

ORLANDI, M ^{[1
]}

FRATTA, W ^{[1
]}

机构：

[1] UNIV CAGLIARI,DEPT NEUROSCI,I-09100 CAGLIARI,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 03期

关键词：

ACTH; Anxiety; Benzodiazepines; Conflict test; Rat; α-MSH;

D O I：

10.1016/0091-3057(90)90267-L

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The intracerebroventricular injection of ACTH1-24 (0.1-10 μg) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by α-MSH (0.25-5 μg), whereas ACTH4-10 and ACTH11-24 were ineffective in does up to 10 μg. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24. © 1990.

引用

页码：631 / 634

页数：4

共 22 条

[11] A BRAIN OCTADECANEUROPEPTIDE GENERATED BY TRYPTIC DIGESTION OF DBI (DIAZEPAM BINDING INHIBITOR) FUNCTIONS AS A PROCONFLICT LIGAND OF BENZODIAZEPINE RECOGNITION SITES [J].