POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAINING A BACKBONE MODIFIED GLUTAMINE

被引：21

作者：

SHAM, HL

ROSENBROOK, W

KATI, W

BETEBENNER, DA

WIDEBURG, NE

SALDIVAR, A

PLATTNER, JJ

NORBECK, DW

机构：

[1] Abbott Laboratories, Pharmaceutical Discovery Division, Department 47D, Abbott Park, IL 60064-3500

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 09期

关键词：

D O I：

10.1039/p19950001081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the common cleavage site (between glutamine and glycine) of the human rhinovirus 3C protease, a series of potent inhibitors of this serine protease containing a backbone modified glutamine has been synthesized.

引用

页码：1081 / 1082

页数：2

共 7 条

[1]

BAZAN JF, 1988, P NATL ACAD SCI USA, V82, P732

[2]

GWALTNEY JM, 1982, VIRAL INFECTION MAN

[3]

KATI WM, 1995, UNPUB BIOCHEMISTRY

[4]

KATRITZKY AR, 1989, SYNTHESIS-STUTTGART, V12, P949

[5]

LEQOG A, 1991, TETRAHEDRON LETT, V32, P2765

[6] PROTEIN PROCESSING MAP OF POLIOVIRUS [J].

PALLANSCH, MA ;

KEW, OM ;

SEMLER, BL ;

OMILIANOWSKI, DR ;

ANDERSON, CW ;

WIMMER, E ;

RUECKERT, RR .

JOURNAL OF VIROLOGY, 1984, 49 (03) :873-880

[7] PICORNAVIRAL PROCESSING - SOME NEW IDEAS [J].

PALMENBERG, AC .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, 33 (03) :191-198

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