FACTORS PREDICTING MORTALITY IN IDIOPATHIC DILATED CARDIOMYOPATHY

被引:104
作者
KOMAJDA, M
JAIS, JP
REEVES, F
GOLDEARB, B
BOUHOUR, JB
JUILLIERES, Y
LANFRANCHI, J
PEYCELON, P
GESLIN, P
CARRIE, D
GROSGOGEAT, Y
机构
[1] HOP NECKER ENFANTS MALAD,DEPT BIOSTAT,PARIS,FRANCE
[2] DEPT CARDIOL,NANCY,FRANCE
[3] DEPT CARDIOL,NANTES,FRANCE
[4] DEPT CARDIOL,BOBIGNY,FRANCE
[5] DEPT CARDIOL,CLERMONT FERRAND,FRANCE
[6] DEPT CARDIOL,ANGERS,FRANCE
[7] DEPT CARDIOL,TOULOUSE,FRANCE
关键词
Dilated cardiomyopathy; Predicting factors; Prognosis;
D O I
10.1093/oxfordjournals.eurheartj.a059803
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A study of factors predicting mortality was performed in 201 patients with dilated cardiomyopathy (163 men, 38 women, mean age: 48 ±11 years) by multivariate analysis (Cox Model) of 51 clinical, electro cardiographic, echocardiographic and haemodynamic parameters, 56 patients died during follow-up (mean followup: 57·1 ± 29·9 months). 5 year survival was 77·3%. The following parameters were independent predictors of mortality: first symptom: pulmonary oedema, peripheral oedema, syncope; duration of symptoms at the time of inclusion; end systolic left ventricular volume; end diastolic left ventricular diameter; pulmonary artery systolic pressure; and their combination had the most accurate predictive value for death. A quantitative score (s) was calculated and used to define three subgroups: A:s ≤4·5; B: 4·5<s<6; C:s ≥ 6. Five-year survival was 90 ± 5% in group A; 84 ± 4% in B and only 53 ±7% in C. In conclusion, overall survival was good in this population of all stage dilated cardiomyopathy; factors related to clinical severity, left ventricular dilation, systolic pulmonary artery pressure and duration of symptoms defined a subgroup of patients with poor prognosis. © 1990 The European Society of Cardiology.
引用
收藏
页码:824 / 831
页数:8
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