A FACILE ENZYMATIC-SYNTHESIS OF GAL-BETA-1,3GLUCAL - A KEY INTERMEDIATE FOR THE SYNTHESIS OF LE(A) AND SIALYL LE(A)

被引：21

作者：

LOOK, GC ^{[1
]}

WONG, CH ^{[1
]}

机构：

[1] Scripps Res Inst, RES INST, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 30期

关键词：

DISACCHARIDE; ENZYMES; GLYCAL; GLYCOSIDASE; REGIOSELECTIVE;

D O I：

10.1016/S0040-4039(00)74231-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several glycosidases have been investigated with respect to their regioselectivity in the formation of glycosidic bonds between various donor sugars and glycal acceptors. Of key interest is the beta-galactosidase-mediated coupling of galactose to glucal affording the beta-1,3-linked disaccharide with high regioselectivity.

引用

页码：4253 / 4256

页数：4

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