KEDARCIDIN, A NEW CHROMOPROTEIN ANTITUMOR ANTIBIOTIC .1. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY

被引：74

作者：

LAM, KS ^{[1
]}

HESLER, GA ^{[1
]}

GUSTAVSON, DR ^{[1
]}

CROSSWELL, AR ^{[1
]}

VEITCH, JM ^{[1
]}

FORENZA, S ^{[1
]}

TOMITA, K ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB RES INST LTD,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 05期

关键词：

D O I：

10.7164/antibiotics.44.472

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Strain L585-6 (ATCC 53650) is an actinomycete isolated from a soil sample collected in Maharastra State, India. It produces a new chromoprotein antitumor antibiotic, designated kedarcidin. Taxonomic studies demonstrated that strain L585-6 is an unidentified and unknown actinomycete. Kedarcidin shows potent antitumor activity against implanted P388 leukemia (3.3-mu-g/ml/kg) and B16 melanoma (2-mu-g/kg) in mice. Kedarcidin also shows potent antimicrobial activity against Gram-positive bacteria but no activity against Gram-negative bacteria.

引用

页码：472 / 478

页数：7

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