FROM AN ANIMAL-MODEL OF AN ATTENTIONAL DEFICIT TOWARDS NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA

被引:103
作者
FELDON, J
WEINER, I
机构
[1] Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel-Aviv
关键词
D O I
10.1016/0022-3956(92)90040-U
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The paper presents an animal model of schizophrenic-like attentional deficit, consisting of an inability to ignore irrelevant stimuli. It is based on the paradigm of latent inhibition (LI), in which animals learn to ignore repeatedly presented stimuli not followed by meaningful consequences. In a series of experiments it was demonstrated that the capacity to ignore irrelevant stimuli is lost in rats treated with systemic or intra-accumbens injections of amphetamine, in normal volunteers given amphetamine, in high ''psychosis-prone'' persons, in acute schizophrenic patients and in untreated male adult rats that were raised until weaning under conditions of extremely restricted stimulation. In addition, LI is lost following the disruption of the hippocampal input to the nucleus accumbens. In all of the above conditions tested for antagonism by anti-psychotic drugs a loss of LI is reversed. On the basis of these results we propose an animal model which accommodates a neurodevelopmental dysfunction, hippocampal pathology, mesolimbic DA overactivity, vulnerability to stress, and gender differences, all of which have been postulated as factors in the pathophysiology of schizophrenia.
引用
收藏
页码:345 / 366
页数:22
相关论文
共 199 条
[1]   EFFECTS OF CS PREEXPOSURES ON AVOIDANCE LEARNING IN RATS WITH HIPPOCAMPAL LESIONS [J].
ACKIL, JE ;
MELLGREN, RL ;
HALGREN, C ;
FROMMER, GP .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1969, 69 (4P1) :739-&
[2]   EFFECTS OF EARLY EXPERIENCE ON ADRENOCORTICAL REACTIVITY [J].
ADER, R ;
GROTA, LJ .
PHYSIOLOGY & BEHAVIOR, 1969, 4 (03) :303-&
[3]  
ANDREASEN NC, 1990, ARCH GEN PSYCHIAT, V47, P35
[4]   THE DISORDER OF CONSCIOUSNESS IN SCHIZOPHRENIA [J].
ANSCOMBE, R .
SCHIZOPHRENIA BULLETIN, 1987, 13 (02) :241-260
[5]  
ASARNOW RF, 1988, ARCH GEN PSYCHIAT, V45, P822
[6]   LATENT INHIBITION AND PSYCHOTIC PRONENESS IN NORMAL SUBJECTS [J].
BARUCH, I ;
HEMSLEY, DR ;
GRAY, JA .
PERSONALITY AND INDIVIDUAL DIFFERENCES, 1988, 9 (04) :777-783
[7]   DIFFERENTIAL PERFORMANCE OF ACUTE AND CHRONIC-SCHIZOPHRENICS IN A LATENT INHIBITION TASK [J].
BARUCH, I ;
HEMSLEY, DR ;
GRAY, JA .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 1988, 176 (10) :598-606
[8]  
BLEULER E, 1911, DEMENTIA PRAECOX
[9]  
BOGERTS B, 1985, ARCH GEN PSYCHIAT, V42, P784
[10]   NEUROPATHOLOGY OF SCHIZOPHRENIAS [J].
BOGERTS, B .
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 1984, 52 (12) :428-437