ISOLATION OF ZOOXANTHELLATOXINS, NOVEL VASOCONSTRICTIVE SUBSTANCES FROM THE ZOOXANTHELLA SYMBIODINIUM SP

被引：39

作者：

NAKAMURA, H

ASARI, T

OHIZUMI, Y

KOBAYASHI, J

YAMASU, T

MURAI, A

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

[2] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

[3] UNIV RYUKYUS,NAHA,OKINAWA 903,JAPAN

来源：

TOXICON | 1993年 / 31卷 / 04期

关键词：

D O I：

10.1016/0041-0101(93)90172-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New polyhydroxypolyenes with potent vasoconstrictive activity, zooxanthellatoxin-A and -B, were isolated from a symbiotic marine alga Symbiodinium sp. These compounds caused sustained contractions of isolated rabbit aorta at concentrations above 7 x 10(-7) M; this effect was abolished in Ca2+-free solution or in the presence of verapamil. Both compounds were relatively large molecules (mol. wt about 2900), containing a large number of oxygen atoms and olefinic carbons, thus differing from two other vasoconstrictive marine toxins, palytoxin and maitotoxin, in containing more olefins than palytoxin, and fewer ethereal rings than maitotoxin.

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页码：371 / 376

页数：6

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