CLONIDINE LOWERS ALPHA-MSH-LIKE IMMUNOREACTIVITY IN HUMAN PLASMA

被引：2

作者：

LIMONE, P ^{[1
]}

DALESSANDRO, V ^{[1
]}

RAINERO, I ^{[1
]}

DEGENNARO, T ^{[1
]}

AMBROGIO, C ^{[1
]}

FULGIDO, G ^{[1
]}

PINESSI, L ^{[1
]}

MOLINATTI, GM ^{[1
]}

机构：

[1] UNIV TURIN,DEPT NEUROL,I-10124 TURIN,ITALY

来源：

LIFE SCIENCES | 1993年 / 53卷 / 22期

关键词：

D O I：

10.1016/0024-3205(93)90207-J

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In a group of seven healthy subjects, the effects of acute intravenous administration of clonidine, a selective alpha2 receptor stimulator, on plasma alpha-MSH-LI concentrations were measured. In comparison with saline, clonidine (0.075 mg) significantly reduced alpha-MSH-LI concentrations, with a maximum fall between 30 and 60 min., followed by a return to basal concentrations at 120 min.; no significant variations in plasma ACTH and cortisol were seen. The precise mechanism of this effect is unclear. Our study suggests that separate regulatory mechanisms exist for the secretion of POMC related peptides in the corticotroph and melanotroph cells of the human pituitary gland.

引用

页码：1703 / 1708

页数：6

共 20 条

[1]

BOLINE P, 1969, SCIENCE, V13, P168

[2] BIOGENIC-AMINES AND CONTROL OF MELANOPHORE STIMULATING HORMONE RELEASE [J].