INVIVO MICRODIALYSIS OF AMINO-ACID NEUROTRANSMITTERS IN THE HIPPOCAMPUS IN AMYGDALOID KINDLED RAT

被引：88

作者：

MINAMOTO, Y

ITANO, T

TOKUDA, M

MATSUI, H

JANJUA, NA

HOSOKAWA, K

OKADA, Y

MURAKAMI, TH

NEGI, T

HATASE, O

机构：

[1] KAGAWA MED SCH,DEPT PHYSIOL,MIKI CHO,KITA KU,KAGAWA 76107,JAPAN

[2] KAGAWA MED SCH,DEPT NEUROPSYCHIAT,KAGAWA,JAPAN

[3] KAGAWA MED SCH,DEPT BIOL,KAGAWA,JAPAN

[4] KAGAWA MED SCH,DEPT HLTH & PHYS EDUC,KAGAWA,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 573卷 / 02期

关键词：

GAMMA-AMINOBUTYRIC ACID; GLUTAMATE; ASPARTATE; MICRODIALYSIS; KINDLING; EPILEPSY;

D O I：

10.1016/0006-8993(92)90786-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular concentrations of gamma-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.

引用

页码：345 / 348

页数：4

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