BONE-MARROW MICROENVIRONMENT AND THE PROGRESSION OF MULTIPLE-MYELOMA

被引：25

作者：

CALIGARISCAPPIO, F

GREGORETTI, MG

MERICO, F

GOTTARDI, D

GHIA, P

PARVIS, G

BERGUI, L

机构：

[1] Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione Clinica, Università di Torino, Torino

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 8卷 / 1-2期

关键词：

B-LYMPHOCYTES; PLASMA CELLS; CYTOKINES; STROMAL CELLS; ADHESION MOLECULES;

D O I：

10.3109/10428199209049813

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The BM microenvironment in MM, in terms of adhesive features, is well organized to entrap circulating precursors with BM-seeking properties and is able to produce cytokines that offer them the optimal conditions for local growth and final differentiation. Likewise, the malignant B cell clone is equipped with adhesion molecules which enable the cell to establish close contacts with BM stromal cells. Furthermore a number of cytokines are released including IL-1beta and M-CSF activating /BM stromal cells/ to produce other cytokines, such as IL-6, that stimulate the proliferation of plasma cells. Finally, most cytokines produced locally, including IL-1beta, TNF-beta, M-CSF, IL-3 and IL-6, also have OAF properties, explaining why the expansion of the B cell clone parallels the activation and numerical increase of the osteoclast population.

引用

页码：15 / 22

页数：8

共 53 条

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