DURABLE COMPLETE REMISSIONS AFTER 2'-DEOXYCOFORMYCIN TREATMENT IN PATIENTS WITH HAIRY-CELL LEUKEMIA RESISTANT TO INTERFERON-ALPHA

被引:26
作者
BLICK, M [1 ]
LEPEZUNIGA, JL [1 ]
DOIG, R [1 ]
QUESADA, JR [1 ]
机构
[1] UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,CTR CANC,DEPT CLIN IMMUNOL & BIOL THERAPY,HOUSTON,TX 77030
关键词
adenosine deaminase inhibitor; DCF; HCL; IFNα;
D O I
10.1002/ajh.2830330309
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The efficacy of interferon alpha in treatment of hairy cell leukemia is well established. Our experience with low doses of 2′‐deoxycoformycin, a competitive inhibitor of adenosine deaminase, showed that it was also effective against hairy cell leukemia in 10 of 11 patients studied whose disease was resistant to interferon alpha. Ten patients entered complete remission after five to 12 doses of 2′‐deoxycoformycin (4 mg/m2 every other week), and one patient did not respond. No relapses were observed after median followup of 18.5 months; unmaintained complete remissions lasted from more than 10 to more than 30 months. The study demonstrated that 2′‐deoxycoformycin induces a high rate of durable, unmaintained complete remissions in patients with hairy cell leukemia resistant to interferon alpha. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:205 / 209
页数:5
相关论文
共 23 条
[1]  
CASTAIGNE S, 1986, CANCER, V57, P1681, DOI 10.1002/1097-0142(19860415)57:8+<1681::AID-CNCR2820571309>3.0.CO
[2]  
2-N
[3]   LEUKEMIC RETICULOENDOTHELIOSIS (HAIRY CELL LEUKEMIA) - DISTINCT CLINICOPATHOLOGICAL ENTITY [J].
CATOVSKY, D ;
PETTIT, JE ;
GALTON, DAG ;
SPIERS, ASD ;
HARRISON, CV .
BRITISH JOURNAL OF HAEMATOLOGY, 1974, 26 (01) :9-&
[4]   CLINICAL-TRIALS IN HAIRY-CELL LEUKEMIA - CURRENT STATUS AND FUTURE-DIRECTIONS [J].
CHESON, BD ;
MARTIN, A .
ANNALS OF INTERNAL MEDICINE, 1987, 106 (06) :871-878
[5]  
FOON KA, 1986, BLOOD, V68, P297
[6]  
FOON KA, 1986, AM J MED, V80, P35
[7]   ALPHA-INTERFERON INDUCES REMISSION IN HAIRY-CELL LEUKEMIA WITHOUT ENHANCEMENT OF NATURAL KILLING [J].
GASTL, G ;
AULITZKY, W ;
LEITER, E ;
FLENER, R ;
HUBER, C .
BLUT, 1986, 52 (05) :273-279
[8]  
GOLOMB HM, 1987, SEMIN ONCOL, V14, P13
[9]  
HAGBERG H, 1985, SCAND J HAEMATOL, V35, P60
[10]   2'-DEOXYCOFORMYCIN (PENTOSTATIN) IN HAIRY-CELL LEUKEMIA - RESPONSE IN PATIENTS REFRACTORY TO INTERFERON ALPHA [J].
HO, AD ;
KUSE, R ;
PRUMMER, O ;
PORZSOLT, F ;
HUNSTEIN, W .
KLINISCHE WOCHENSCHRIFT, 1987, 65 (20) :975-979