THE GENE FOR HUMAN ACIDIC FIBROBLAST GROWTH-FACTOR ENCODES 2 UPSTREAM EXONS ALTERNATIVELY SPLICED TO THE 1ST CODING EXON

被引：17

作者：

CRUMLEY, G

DIONNE, CA

JAYE, M

机构：

[1] Rorer Central Research, King of Prussia, PA 19406

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91348-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated two cDNA clones encoding human acidic fibroblast growth factor (aFGF) which represent the utilization of alternative upstream exons in aFGF mRNA. Isolation and sequence analysis of genomic clones spanning the first coding exon and each of the upstream sequences confirms that the divergent 5′ sequences are separate exons, spliced alternatively to the first coding exon 34 nucleotides upstream of the initiator AUG codon. Restriction mapping of the genomic clones provides a minimum size estimate of 45 kilobase pairs for the aFGF locus. © 1990.

引用

页码：7 / 13

页数：7

共 24 条

[1] AN ONCOGENE ISOLATED BY TRANSFECTION OF KAPOSIS-SARCOMA DNA ENCODES A GROWTH-FACTOR THAT IS A MEMBER OF THE FGF FAMILY [J].