ENDOTHELIUM-DERIVED AND INTRANEURONAL NITRIC OXIDE-DEPENDENT INHIBITION OF NOREPINEPHRINE EFFLUX FROM SYMPATHETIC-NERVES BY BRADYKININ

被引：35

作者：

GREENBERG, SS

PEEVY, K

TANAKA, TP

机构：

[1] Departments of Pediatrics, Pharmacology College of Medicine, University of South Alabama, Mobile

[2] Departments of Pharmacology, Oral Anatomy, Kyushu University, Fukuoka

[3] Department of Pharmacology, School of Medicine, University of North Dakota, Grand Forks, ND

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 05期

关键词：

BRADYKININ; ARGININE; NITRIC OXIDE; SMOOTH MUSCLE; NEUROTRANSMISSION;

D O I：

10.1093/ajh/4.5.464

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium. Moreover, in the absence of vascular endothelium, bradykinin also inhibits norepinephrine efflux from the sympathetic nerve terminals innervating these blood vessels. This inhibition is attenuated by canavanine and LNMMA, which inhibit the conversion of arginine to nitric oxide, and is enhanced after overnight incubation of blood vessels with arginine. In endothelium-rubbed blood vessels the inhibitory effect of bradykinin on norepinephrine efflux is enhanced by increasing extracellular calcium ion ([Ca2+]o) and attenuated by nitrendipine. We propose that bradykinin inhibits norepinephrine efflux by stimulating intraneuronal nitric oxide from arginine.

引用

页码：464 / 467

页数：4

共 15 条

[1] Aksoy M.O., Harakal C., Smith J.B., Et al., Mediation of bradykinin-induced contraction in canine veins via throm-boxane/prostaglandin endoperoxide receptor activation, Br J Pharmacol, 99, pp. 461-466, (1990)
[2] Goldberg M.R., Joiner P.D., Greenberg S., Et al., Effects ofindomethacin on venoconstrictor responses to bradykinin and norepinephrine, Prostaglandins, 9, pp. 385-390, (1975)
[3] Reiser G., Walter U., Hamprecht B., Bradykinin regulatesthe level of guanosine 3', 5'-cyclic monophosphate (Cyclic GMP) in neural cell lines, Brain Res, 290, pp. 367-371, (1984)
[4] Owen P.J., Pievin R., Boarder M.R., Characterization of bra-dykinin-stimulated release of noradrenaline from cultured bovine adrenal chromaffin cells, J Pharmacol ExpTher, 248, pp. 1231-1236, (1989)
[5] Malik K.U., Nasjletti A., Inhibitory action of bradykinin onrelease of the adrenergic transmitter in the isolated lapine kidney, Experientia, 37, pp. 496-497, (1981)
[6] Burgess G.M., Mullaney I., McNeill M., Et al., Activation ofguanylate cyclase by bradykinin in rat sensory neuronesis mediated by calcium influx: Possible role of the increase in cyclic GMP, J Neurochem, 53, pp. 1212-1218, (1989)
[7] Furchgott R.F., Vanhoutte P.M., Endothelium-derived relaxing and contracting factors, FASEB J, 3, pp. 2007-2018, (1989)
[8] Gorsky L.D., Forstermann U., Ishii K., Et al., Production ofan EDRF-like activity in the cytosol of N1E-115 neuroblastoma cells, FASEB J, 4, pp. 1494-1500, (1990)
[9] Palacios M., Knowles R.G., Palmer R., Et al., Nitric oxidefrom L-arginine stimulates the soluble guanylate cyclasein adrenal glands, Biochem Biophys Res Commun, 165, pp. 802-809, (1989)
[10] Greenberg S., Diecke F., Peevy K., Et al., Endotheliummodulation of norepinephrine release from adrenergicnerve endings of canine pulmonary arteries and veins, Eur J Pharmacol, 162, pp. 67-80, (1989)

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