DOTHIEPIN VERSUS AMITRIPTYLINE FOR DEPRESSION - AN ANALYSIS OF COMPARATIVE-STUDIES

被引：3

作者：

DONOVAN, S

VLOTTES, PW

MIN, JM

机构：

[1] Research Department, Boots Pharmaceuticals, Nottingham

[2] Boots Pharmaceuticals (Holland) B.V., Hilversum

来源：

DRUG INVESTIGATION | 1991年 / 3卷 / 03期

关键词：

D O I：

10.1007/BF03259561

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A review of the English language literature comparing amitriptyline and dothiepin in depression revealed a consistent pattern of findings. 23 independent studies performed in 8 countries over an 18-year period between 1971 and 1988 in over 1000 evaluable patients indicates that dothiepin is at least as effective as amitriptyline but is better tolerated. The consistent pattern of findings in these studies suggests that dothiepin is a better alternative to amitriptyline in the treatment of depression.

引用

页码：178 / 182

页数：5

共 22 条

[1]

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[2]

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[3]

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[4]

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[5]

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[6]

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[7]

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[8]

Joshi V.S., Gangdev P., De Sousa A., Kulkarni R.D., A comparative study of dothiepin and amitriptyline in major depression, Journal of Community Psychiatry, 11, pp. 27-31, (1988)

[9]

Khan A.U., A comparison of the therapeutic and cardiovascular effects of a single nightly dose of Prothiaden (dothiepin, Dosulepin) and Lentizol (sustained release amitriptyline) in depressed elderly patients, Journal of International Medical Research, 9, pp. 108-112, (1981)

[10]

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