DIFFERENTIAL AXONAL-TRANSPORT OF INDIVIDUAL NA,K-ATPASE CATALYTIC (ALPHA) SUBUNIT ISOFORMS IN RAT SCIATIC-NERVE

被引：18

作者：

MATA, M ^{[1
]}

DATTA, S ^{[1
]}

JIN, CF ^{[1
]}

FINK, DJ ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109

来源：

BRAIN RESEARCH | 1993年 / 618卷 / 02期

关键词：

ADENOSINE TRIPHOSPHATASE; SODIUM POTASSIUM; AXONAL TRANSPORT; AXON; NEURON; SCHWANN CELL; WESTERN BLOT;

D O I：

10.1016/0006-8993(93)91278-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Three isoforms of the Na,K-ATPase catalytic (alpha) subunit are present in neurons, demonstrated by in situ hybridization of neurons and Western blot of nerve. We used Western blot with antibodies specific for alpha1, alpha2 and alpha3 peptides to measure the accumulation of individual peptides at a ligature on the sciatic nerve. Alpha1 peptide accumulated with kinetics suggesting rapid axonal transport of that isoform within nerve. Alpha2 and alpha3 peptides did not accumulate at the ligature. These studies provide insight into the dynamics of axonal Na,K-ATPase isoforms.

引用

页码：295 / 298

页数：4

共 14 条

[1]

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[2]

ARIYASU RG, 1985, J NEUROSCI, V5, P2581

[3]

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[4] INTRACELLULAR-TRANSPORT IN NEURONS [J].