INFECTION BY ECHOVIRUSES-1 AND ECHOVIRUSES-8 DEPENDS ON THE ALPHA-2 SUBUNIT OF HUMAN VLA-2

被引：89

作者：

BERGELSON, JM

STJOHN, N

KAWAGUCHI, S

CHAN, M

STUBDAL, H

MODLIN, J

FINBERG, RW

机构：

[1] DARTMOUTH HITCHCOCK MED CTR,INFECT DIS SECT,LEBANON,NH 03756

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR VIROL,BOSTON,MA 02115

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 11期

关键词：

D O I：

10.1128/JVI.67.11.6847-6852.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha2 subunit of human VLA-2. These results indicate that the human alpha2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.

引用

页码：6847 / 6852

页数：6

共 19 条

[1]

BERG G, 1961, J BACTERIOL, V83, P556

[2] IDENTIFICATION OF THE INTEGRIN VLA-2 AS A RECEPTOR FOR ECHOVIRUS-1 [J].