ASCORBATE FREE-RADICAL AND ITS ROLE IN GROWTH-CONTROL

被引:24
作者
NAVAS, P
GOMEZDIAZ, C
机构
[1] Departamento de Biología Celular, Facultad de Ciencias, Universidad de Córdoba, Córdoba, E-14004, Avda. San Alberto Magno s/n
关键词
ASCORBATE; ASCORBATE FREE RADICAL; HL-60; CELLS; CCL39; GROWTH; PLASMA MEMBRANE REDOX SYSTEM;
D O I
10.1007/BF01276895
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ascorbate and its free radical potentiates proliferation of HL-60 cells in serum-limiting media. Dehydroascorbate does not affect growth. This stimulation of growth is due to a general shortening of the cell cycle. The incubation of HL-60 cells with ascorbate free radical produces a significant change of the redox potential of cells. The presence of cells in culture media avoids the total oxidation of ascorbate, and also HL-60 cells induce the short-term stabilization of ascorbate. Ascorbate free radical potentiates also the onset of DNA synthesis in CCL39 cells induced by fetal calf serum, although itself does not affect quiescense to proliferation transition. This transition induced by fetal calf serum also potentiates the capacity of CCL39 cells to stabilize ascorbate. We discuss here the role of ascorbate free radical on growth control by its reduction by the plasma membrane redox system and its meaning for cell physioslogy.
引用
收藏
页码:8 / 13
页数:6
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