PROSTAGLANDIN-E2 RELEASED BY PRE-IMPLANTATION HUMAN CONCEPTUSES

被引：37

作者：

HOLMES, PV ^{[1
]}

SJOGREN, A ^{[1
]}

HAMBERGER, L ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT OBSTET & GYNECOL,S-41124 GOTHENBURG,SWEDEN

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1990年 / 17卷 / 01期

关键词：

blastocyst; decidual reaction; human conceptus; immuno-suppression; implantation; prostaglandin;

D O I：

10.1016/0165-0378(90)90041-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This work investigates the production of postaglandin E2 (PGE2), a well known modulator for the suppression of immune cells, by pre-implantation human conceptuses from the 4-cell stage to the hatched blastocyst and by cumulus oophorus cells, these being obtained from an IVF/ET program. Cumulus cell complexes cultured for 48 h produced considerable amounts of PGE2, necessitating complete removal of their influence on the conceptus cultures. All stages of the human conceptus studied produced PGE2 during 48-h cultures, the greatest amounts from late blastocysts, and from those cultured in media containing bovine serum albumin rather than human donor serum. Indomethacin-treated control blastocysts confirmed the synthesis and release from the human conceptuses. The production of PGF2a from human blastocysts could not be demonstrated. © 1990.

引用

页码：79 / 86

页数：8

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